Wound Healing Activity of Ethanolic Extract of Bryophyllum calycinum Salisb

Bryophyllum calycinum Salisb (Crassulaceae) a shrub mainly found in the tropical parts of Bengal and in southern African and American continents. It is locally known as Patharkuchiì and for long has been used in ayurvedic medicine. It has been reported for its hepatoprotective, neuropharmacological, antimutagenic, antihistaminic, antibacterial, antinociceptive, antidiabetic and antiinflammatory activities. Besides these activities, it has been traditionally reported that B. calycinum is useful for the treatment of wounds in Nigerian herbal medicines. The leaf extract of B. calycinum has been reported for its wound healing activity. The present study aims to evaluate the wound healing potential of the whole plant of B. calycinum as traditional medicine healers in southeastern Nigeria often use the entire shurb in treating wounds and burns. The whole plant of B. calycinum was extracted with ethanol and subjected to chemical characterization. The dried extract was evaluated for its acute toxicity and wound healing activity in excision, incision and dead space wound models.